How to use prep(preexposure prophylaxis) in the prevention of HIV/AIDS

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The 4 ways to take PrEP.

How you take your PrEP depends on:

  • how far in advance you plan on having sex
  • how regularly you have sex.

It does not necessarily depend on how much sex you have.

Check for other interactions with other drugs here.

Switching between dosing options

There are slightly different recommendations for anal sex and vaginal or frontal sex.

We recommend daily PrEP (including holiday PrEP) for all trans people using hormone treatment as we don’t have sufficient data to support other dosing options.

Switching between dosing options to match your sexual activity and patterns is totally OK. You can adjust your PrEP regime to best suit you as your situation changes.

Remember that:

  • On Demand dosing (or Event Based Dosing) and 4 pills per week are methods suitable only for anal sex.
  • Daily PrEP and Holiday PrEP are the only methods of taking PrEP that are suitable for both anal and vaginal or frontal sex.

We know that a minimum of 6 pills per week is required for adequate for anal and vaginal sex




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